Story:
Chloe (voice of DREW BARRYMORE), a diamond-clad, bootie wearing Beverly Hills Chihuahua enjoys her luxurious lifestyle so much, she hardly notices Papi (voice of GEORGE LOPEZ), a hilarious Chihuahua who happens to be crazy for Chloe. But when the most pampered pooch gets lost in Mexico with only a street-wise German Shepherd (voice of ANDY GARCIA) to help her find her way home, Papi heads south of the border—joining forces with a motley crew: three dogs (voices of PLÁCIDO DOMINGO, LUIS GUZMAN and EDDIE “PIOLIN” SOTELO), two humans (PIPER PERABO, MANOLO CARDONA), a sly rat (voice of CHEECH MARIN) and a nervous iguana (voice of PAUL RODRIGUEZ)—to rescue his true love.