Identical twins, Alex Fielding (Tia Mowry) and Camryn Barnes (Tamera Mowry) are born in Coventry, a magical kingdom, and separated at birth when their father sends them to Earth to protect them from the evil forces of Darkness. Unaware of each others existence, the girls are adopted by two different families and grow up in opposite worlds – Alex in a small one bedroom apartment with a working-class mother while Camryn lives in a mansion and wants for nothing. The two are assigned protectors at birth, Ileana for Alex and Karsh for Camryn, who watch over their every move. Ultimately, it's Ileana and Karsh who bring Alex and Camryn together on their 21st birthday. When the girls reunite, their powers start to come into form and their birth mother Miranda, who thought her precious daughters were dead, can sense they are alive. While Alex and Camryn struggle to accept the truth about their past and the extent of their magic, they set out to find their birth mother to get the answers they are looking for. But when they realize that they are the only ones who can save Coventry, Alex and Camryn unite to fight the evil forces of Darkness that threatens to destroy them.

Starring are Tia Mowry ("Sister, Sister") and Tamera Mowry ("Sister, Sister," "Strong Medicine"), Kristen Wilson ("Dr. Doolittle") as Miranda, Jackie Rosenbaum as Beth Fish, Jessica Greco as Lucinda, Pat Kelly as Karsh, Jennifer Robertson as Ileana and Patrick Fabian as Thantos.

"Twitches" was written by Dan Berendsen (Disney Channel's "Stuck in the Suburbs") and is directed by Stuart Gillard (Disney Channel's "Going to the Mat"). The producer is Kevin Lafferty (Disney Channel's "Cadet Kelly") with Carla Singer serving as executive producer and Joan Carson as co-executive producer. "Twitches" is a production of Broomsticks Productions Ltd. for Disney Channel.